| GO:0000156 | 1.000 | 0.999 | | | 1.000 | two-component response regulator activity |
| GO:0004871 | 0.990 | 0.995 | | | 0.992 | signal transducer activity |
| GO:0060089 | 0.983 | 0.989 | | | 0.986 | molecular transducer activity |
| GO:0000287 | 0.971 | 0.956 | | | 0.963 | magnesium ion binding |
| GO:0008855 | 0.750 | 0.998 | | | 0.874 | exodeoxyribonuclease VII activity |
| GO:0003899 | 0.740 | 0.999 | | | 0.870 | DNA-directed RNA polymerase activity |
| GO:0030528 | 0.653 | 0.992 | | | 0.822 | transcription regulator activity |
| GO:0046992 | 0.539 | 0.999 | | | 0.769 | oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond |
| GO:0015293 | 0.534 | 0.996 | | | 0.765 | symporter activity |
| GO:0016746 | 0.507 | 0.988 | | | 0.748 | transferase activity, transferring acyl groups |
| GO:0008234 | 0.457 | 0.998 | | | 0.728 | cysteine-type peptidase activity |
| GO:0008171 | 0.451 | 0.999 | | | 0.725 | O-methyltransferase activity |
| GO:0016853 | 0.340 | 0.999 | | | 0.669 | isomerase activity |
| GO:0004300 | 0.297 | 0.998 | | | 0.648 | enoyl-CoA hydratase activity |
| GO:0015149 | 0.276 | 0.998 | | | 0.637 | hexose transmembrane transporter activity |
| GO:0003700 | 0.287 | 0.975 | | | 0.631 | transcription factor activity |
| GO:0016722 | 0.265 | 0.996 | | | 0.631 | oxidoreductase activity, oxidizing metal ions |
| GO:0016773 | 0.193 | 0.996 | | | 0.595 | phosphotransferase activity, alcohol group as acceptor |
| GO:0016817 | 0.257 | 0.921 | | | 0.589 | hydrolase activity, acting on acid anhydrides |
| GO:0016462 | 0.256 | 0.922 | | | 0.589 | pyrophosphatase activity |