| GO:0004518 | 0.982 | 0.996 | | | 0.989 | nuclease activity |
| GO:0009036 | 0.908 | 0.997 | | | 0.953 | Type II site-specific deoxyribonuclease activity |
| GO:0004888 | 0.709 | 0.998 | | | 0.853 | transmembrane receptor activity |
| GO:0051002 | 0.601 | 0.998 | | | 0.799 | ligase activity, forming nitrogen-metal bonds |
| GO:0016564 | 0.456 | 0.998 | | | 0.727 | transcription repressor activity |
| GO:0016705 | 0.389 | 0.998 | | | 0.694 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
| GO:0000150 | 0.370 | 0.999 | | | 0.685 | recombinase activity |
| GO:0008234 | 0.358 | 0.998 | | | 0.678 | cysteine-type peptidase activity |
| GO:0019104 | 0.475 | 0.844 | | | 0.659 | DNA N-glycosylase activity |
| GO:0016708 | 0.292 | 0.998 | | | 0.645 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor |
| GO:0015925 | 0.250 | 0.997 | | | 0.623 | galactosidase activity |
| GO:0005506 | 0.213 | 0.997 | | | 0.605 | iron ion binding |
| GO:0003700 | 0.300 | 0.877 | | | 0.589 | transcription factor activity |
| GO:0016893 | 0.990 | 0.181 | | | 0.585 | endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters |
| GO:0016888 | 0.982 | 0.152 | | | 0.567 | endodeoxyribonuclease activity, producing 5'-phosphomonoesters |
| GO:0004497 | 0.112 | 0.997 | | | 0.555 | monooxygenase activity |
| GO:0004536 | 0.867 | 0.221 | | | 0.544 | deoxyribonuclease activity |
| GO:0016811 | 0.083 | 0.996 | | | 0.540 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides |
| GO:0016726 | 0.075 | 1.000 | | | 0.537 | oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor |
| GO:0051213 | 0.053 | 0.995 | | | 0.524 | dioxygenase activity |