| GO:0016757 | 1.000 | 0.988 | | | 0.994 | transferase activity, transferring glycosyl groups |
| GO:0016651 | 0.993 | 0.993 | | | 0.993 | oxidoreductase activity, acting on NADH or NADPH |
| GO:0020037 | 0.995 | 0.975 | | | 0.985 | heme binding |
| GO:0005215 | 0.995 | 0.960 | | | 0.977 | transporter activity |
| GO:0009055 | 0.950 | 0.996 | | | 0.973 | electron carrier activity |
| GO:0017153 | 0.917 | 0.999 | | | 0.958 | sodium:dicarboxylate symporter activity |
| GO:0051183 | 0.891 | 0.995 | | | 0.943 | vitamin transporter activity |
| GO:0008324 | 0.919 | 0.961 | | | 0.940 | cation transmembrane transporter activity |
| GO:0016701 | 0.925 | 0.925 | | | 0.925 | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen |
| GO:0016676 | 0.904 | 0.944 | | | 0.924 | oxidoreductase activity, acting on heme group of donors, oxygen as acceptor |
| GO:0015300 | 0.840 | 0.999 | | | 0.920 | solute:solute antiporter activity |
| GO:0016709 | 0.841 | 0.998 | | | 0.920 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen |
| GO:0004129 | 0.966 | 0.867 | | | 0.916 | cytochrome-c oxidase activity |
| GO:0005507 | 0.975 | 0.856 | | | 0.916 | copper ion binding |
| GO:0004190 | 0.976 | 0.852 | | | 0.914 | aspartic-type endopeptidase activity |
| GO:0015932 | 0.854 | 0.963 | | | 0.908 | nucleobase, nucleoside, nucleotide and nucleic acid transmembrane transporter activity |
| GO:0005310 | 0.892 | 0.909 | | | 0.901 | dicarboxylic acid transmembrane transporter activity |
| GO:0051119 | 0.805 | 0.994 | | | 0.900 | sugar transmembrane transporter activity |
| GO:0047134 | 0.799 | 0.999 | | | 0.899 | protein-disulfide reductase activity |
| GO:0046943 | 0.966 | 0.797 | | | 0.882 | carboxylic acid transmembrane transporter activity |