| GO:0003887 | 1.000 | 0.996 | | | 0.998 | DNA-directed DNA polymerase activity |
| GO:0004529 | 0.899 | 0.996 | | | 0.948 | exodeoxyribonuclease activity |
| GO:0008081 | 0.920 | 0.957 | | | 0.939 | phosphoric diester hydrolase activity |
| GO:0016832 | 0.821 | 1.000 | | | 0.910 | aldehyde-lyase activity |
| GO:0004518 | 0.813 | 0.996 | | | 0.905 | nuclease activity |
| GO:0016818 | 0.765 | 0.919 | | | 0.842 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides |
| GO:0016462 | 0.757 | 0.922 | | | 0.840 | pyrophosphatase activity |
| GO:0009008 | 0.804 | 0.791 | | | 0.797 | DNA-methyltransferase activity |
| GO:0008234 | 0.572 | 0.936 | | | 0.754 | cysteine-type peptidase activity |
| GO:0016776 | 0.505 | 0.992 | | | 0.748 | phosphotransferase activity, phosphate group as acceptor |
| GO:0016986 | 0.488 | 0.998 | | | 0.743 | transcription initiation factor activity |
| GO:0016837 | 0.480 | 0.998 | | | 0.739 | carbon-oxygen lyase activity, acting on polysaccharides |
| GO:0009036 | 0.995 | 0.405 | | | 0.700 | Type II site-specific deoxyribonuclease activity |
| GO:0016725 | 0.395 | 0.996 | | | 0.696 | oxidoreductase activity, acting on CH or CH2 groups |
| GO:0015666 | 0.997 | 0.379 | | | 0.688 | restriction endodeoxyribonuclease activity |
| GO:0051002 | 0.352 | 0.998 | | | 0.675 | ligase activity, forming nitrogen-metal bonds |
| GO:0016895 | 0.352 | 0.997 | | | 0.675 | exodeoxyribonuclease activity, producing 5'-phosphomonoesters |
| GO:0016831 | 0.358 | 0.986 | | | 0.672 | carboxy-lyase activity |
| GO:0004725 | 0.332 | 0.999 | | | 0.666 | protein tyrosine phosphatase activity |
| GO:0005509 | 0.762 | 0.565 | | | 0.664 | calcium ion binding |