| GO:0009008 | 1.000 | 0.997 | | | 0.998 | DNA-methyltransferase activity |
| GO:0009007 | 0.996 | 0.997 | | | 0.997 | site-specific DNA-methyltransferase (adenine-specific) activity |
| GO:0004518 | 0.783 | 0.996 | | | 0.890 | nuclease activity |
| GO:0016893 | 0.676 | 0.996 | | | 0.836 | endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters |
| GO:0004519 | 0.456 | 1.000 | | | 0.728 | endonuclease activity |
| GO:0003887 | 0.339 | 0.996 | | | 0.667 | DNA-directed DNA polymerase activity |
| GO:0003677 | 0.368 | 0.950 | | | 0.659 | DNA binding |
| GO:0009036 | 0.777 | 0.405 | | | 0.591 | Type II site-specific deoxyribonuclease activity |
| GO:0016741 | 0.162 | 0.977 | | | 0.570 | transferase activity, transferring one-carbon groups |
| GO:0008757 | 0.116 | 0.984 | | | 0.550 | S-adenosylmethionine-dependent methyltransferase activity |
| GO:0008081 | 0.772 | 0.300 | | | 0.536 | phosphoric diester hydrolase activity |
| GO:0003700 | 0.090 | 0.975 | | | 0.533 | transcription factor activity |
| GO:0046906 | 0.044 | 0.993 | | | 0.518 | tetrapyrrole binding |
| GO:0004540 | 0.035 | 0.995 | | | 0.515 | ribonuclease activity |
| GO:0004857 | 0.021 | 0.999 | | | 0.510 | enzyme inhibitor activity |
| GO:0005102 | 0.031 | 0.988 | | | 0.510 | receptor binding |
| GO:0008173 | 0.018 | 0.998 | | | 0.508 | RNA methyltransferase activity |
| GO:0030246 | 0.018 | 0.994 | | | 0.506 | carbohydrate binding |
| GO:0060089 | 0.013 | 0.989 | | | 0.501 | molecular transducer activity |
| GO:0016894 | 0.000 | 1.000 | | | 0.500 | endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters |