| GO:0003918 | 1.000 | 0.998 | | | 0.999 | DNA topoisomerase (ATP-hydrolyzing) activity |
| GO:0016853 | 1.000 | 0.970 | | | 0.985 | isomerase activity |
| GO:0003677 | 0.993 | 0.950 | | | 0.972 | DNA binding |
| GO:0004527 | 0.979 | 0.793 | | | 0.886 | exonuclease activity |
| GO:0051003 | 0.667 | 0.925 | | | 0.796 | ligase activity, forming nitrogen-metal bonds, forming coordination complexes |
| GO:0016888 | 0.821 | 0.732 | | | 0.776 | endodeoxyribonuclease activity, producing 5'-phosphomonoesters |
| GO:0004518 | 0.757 | 0.726 | | | 0.741 | nuclease activity |
| GO:0016775 | 0.975 | 0.397 | | | 0.686 | phosphotransferase activity, nitrogenous group as acceptor |
| GO:0004871 | 0.960 | 0.294 | | | 0.627 | signal transducer activity |
| GO:0009036 | 0.808 | 0.405 | | | 0.607 | Type II site-specific deoxyribonuclease activity |
| GO:0004673 | 0.811 | 0.386 | | | 0.598 | protein histidine kinase activity |
| GO:0004519 | 0.134 | 0.987 | | | 0.561 | endonuclease activity |
| GO:0046870 | 0.882 | 0.219 | | | 0.551 | cadmium ion binding |
| GO:0031419 | 0.335 | 0.727 | | | 0.531 | cobalamin binding |
| GO:0051002 | 0.802 | 0.248 | | | 0.525 | ligase activity, forming nitrogen-metal bonds |
| GO:0016832 | 0.047 | 1.000 | | | 0.523 | aldehyde-lyase activity |
| GO:0003916 | 1.000 | 0.000 | | | 0.500 | DNA topoisomerase activity |
| GO:0019120 | 0.000 | 0.998 | | | 0.499 | hydrolase activity, acting on acid halide bonds, in C-halide compounds |
| GO:0015415 | 0.000 | 0.998 | | | 0.499 | phosphate transmembrane-transporting ATPase activity |
| GO:0008718 | 0.000 | 0.997 | | | 0.499 | D-amino-acid dehydrogenase activity |