| GO:0004518 | 1.000 | 0.996 | | | 0.998 | nuclease activity |
| GO:0004803 | 0.996 | 1.000 | | | 0.998 | transposase activity |
| GO:0015666 | 0.996 | 0.997 | | | 0.997 | restriction endodeoxyribonuclease activity |
| GO:0016722 | 0.989 | 0.996 | | | 0.993 | oxidoreductase activity, oxidizing metal ions |
| GO:0016860 | 0.981 | 0.999 | | | 0.990 | intramolecular oxidoreductase activity |
| GO:0001882 | 0.981 | 0.997 | | | 0.989 | nucleoside binding |
| GO:0015932 | 0.978 | 0.997 | | | 0.988 | nucleobase, nucleoside, nucleotide and nucleic acid transmembrane transporter activity |
| GO:0004519 | 0.963 | 1.000 | | | 0.982 | endonuclease activity |
| GO:0004747 | 0.961 | 0.998 | | | 0.980 | ribokinase activity |
| GO:0009008 | 0.961 | 0.996 | | | 0.979 | DNA-methyltransferase activity |
| GO:0051002 | 0.957 | 0.997 | | | 0.977 | ligase activity, forming nitrogen-metal bonds |
| GO:0016708 | 0.952 | 0.998 | | | 0.975 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor |
| GO:0051003 | 0.935 | 0.999 | | | 0.967 | ligase activity, forming nitrogen-metal bonds, forming coordination complexes |
| GO:0004333 | 0.927 | 0.996 | | | 0.961 | fumarate hydratase activity |
| GO:0004529 | 0.918 | 0.998 | | | 0.958 | exodeoxyribonuclease activity |
| GO:0009007 | 0.902 | 0.997 | | | 0.950 | site-specific DNA-methyltransferase (adenine-specific) activity |
| GO:0034062 | 0.895 | 0.997 | | | 0.946 | RNA polymerase activity |
| GO:0015149 | 0.880 | 0.997 | | | 0.939 | hexose transmembrane transporter activity |
| GO:0016893 | 0.876 | 0.925 | | | 0.901 | endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters |
| GO:0008565 | 0.799 | 0.998 | | | 0.899 | protein transporter activity |