| GO:0015666 | 0.925 | 0.945 | | | 0.935 | restriction endodeoxyribonuclease activity |
| GO:0009036 | 0.807 | 0.999 | | | 0.903 | Type II site-specific deoxyribonuclease activity |
| GO:0003700 | 0.678 | 0.725 | | | 0.702 | transcription factor activity |
| GO:0008135 | 0.380 | 0.992 | | | 0.686 | translation factor activity, nucleic acid binding |
| GO:0016893 | 0.357 | 0.996 | | | 0.677 | endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters |
| GO:0045182 | 0.319 | 0.992 | | | 0.656 | translation regulator activity |
| GO:0016888 | 0.465 | 0.827 | | | 0.646 | endodeoxyribonuclease activity, producing 5'-phosphomonoesters |
| GO:0004620 | 0.276 | 0.997 | | | 0.637 | phospholipase activity |
| GO:0016423 | 0.191 | 0.997 | | | 0.594 | tRNA (guanine) methyltransferase activity |
| GO:0043176 | 0.140 | 0.998 | | | 0.569 | amine binding |
| GO:0042802 | 0.120 | 0.998 | | | 0.559 | identical protein binding |
| GO:0008270 | 0.157 | 0.949 | | | 0.553 | zinc ion binding |
| GO:0010181 | 0.111 | 0.995 | | | 0.553 | FMN binding |
| GO:0016627 | 0.080 | 0.988 | | | 0.534 | oxidoreductase activity, acting on the CH-CH group of donors |
| GO:0004803 | 0.964 | 0.079 | | | 0.521 | transposase activity |
| GO:0004222 | 0.040 | 1.000 | | | 0.520 | metalloendopeptidase activity |
| GO:0016702 | 0.036 | 0.998 | | | 0.517 | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen |
| GO:0046857 | 0.029 | 0.999 | | | 0.514 | oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor |
| GO:0051213 | 0.032 | 0.995 | | | 0.513 | dioxygenase activity |
| GO:0004871 | 0.009 | 0.995 | | | 0.502 | signal transducer activity |