| GO:0016701 | 1.000 | 0.999 | | | 1.000 | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen |
| GO:0008199 | 1.000 | 0.999 | | | 1.000 | ferric iron binding |
| GO:0016702 | 1.000 | 0.998 | | | 0.999 | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen |
| GO:0016788 | 0.978 | 0.998 | | | 0.988 | hydrolase activity, acting on ester bonds |
| GO:0016491 | 0.986 | 0.923 | | | 0.955 | oxidoreductase activity |
| GO:0016708 | 0.803 | 0.998 | | | 0.901 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor |
| GO:0005198 | 0.787 | 0.989 | | | 0.888 | structural molecule activity |
| GO:0051002 | 0.784 | 0.941 | | | 0.862 | ligase activity, forming nitrogen-metal bonds |
| GO:0016298 | 0.704 | 0.997 | | | 0.850 | lipase activity |
| GO:0015926 | 0.696 | 0.997 | | | 0.846 | glucosidase activity |
| GO:0003700 | 0.527 | 0.975 | | | 0.751 | transcription factor activity |
| GO:0008649 | 0.490 | 0.996 | | | 0.743 | rRNA methyltransferase activity |
| GO:0003916 | 0.425 | 0.998 | | | 0.712 | DNA topoisomerase activity |
| GO:0004872 | 0.589 | 0.833 | | | 0.711 | receptor activity |
| GO:0004867 | 0.406 | 0.998 | | | 0.702 | serine-type endopeptidase inhibitor activity |
| GO:0051287 | 0.303 | 0.998 | | | 0.651 | NAD binding |
| GO:0000155 | 0.271 | 0.994 | | | 0.633 | two-component sensor activity |
| GO:0016645 | 0.284 | 0.954 | | | 0.619 | oxidoreductase activity, acting on the CH-NH group of donors |
| GO:0016779 | 0.225 | 0.996 | | | 0.611 | nucleotidyltransferase activity |
| GO:0004659 | 0.214 | 0.999 | | | 0.607 | prenyltransferase activity |