| GO:0008170 | 1.000 | 0.998 | | | 0.999 | N-methyltransferase activity |
| GO:0016741 | 0.951 | 0.977 | | | 0.964 | transferase activity, transferring one-carbon groups |
| GO:0008168 | 0.946 | 0.979 | | | 0.963 | methyltransferase activity |
| GO:0008757 | 0.884 | 0.984 | | | 0.934 | S-adenosylmethionine-dependent methyltransferase activity |
| GO:0008081 | 0.833 | 0.999 | | | 0.916 | phosphoric diester hydrolase activity |
| GO:0030528 | 0.768 | 0.992 | | | 0.880 | transcription regulator activity |
| GO:0004888 | 0.665 | 0.998 | | | 0.831 | transmembrane receptor activity |
| GO:0019239 | 0.658 | 0.992 | | | 0.825 | deaminase activity |
| GO:0016846 | 0.625 | 0.997 | | | 0.811 | carbon-sulfur lyase activity |
| GO:0004872 | 0.524 | 0.996 | | | 0.760 | receptor activity |
| GO:0008649 | 0.612 | 0.852 | | | 0.732 | rRNA methyltransferase activity |
| GO:0051003 | 0.360 | 0.999 | | | 0.679 | ligase activity, forming nitrogen-metal bonds, forming coordination complexes |
| GO:0004620 | 0.269 | 0.997 | | | 0.633 | phospholipase activity |
| GO:0016773 | 0.251 | 0.984 | | | 0.617 | phosphotransferase activity, alcohol group as acceptor |
| GO:0004594 | 0.206 | 0.998 | | | 0.602 | pantothenate kinase activity |
| GO:0016986 | 0.196 | 0.998 | | | 0.597 | transcription initiation factor activity |
| GO:0016705 | 0.153 | 0.998 | | | 0.576 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
| GO:0009008 | 1.000 | 0.109 | | | 0.554 | DNA-methyltransferase activity |
| GO:0016423 | 0.090 | 0.997 | | | 0.544 | tRNA (guanine) methyltransferase activity |
| GO:0030151 | 0.044 | 0.997 | | | 0.520 | molybdenum ion binding |