| GO:0016646 | 1.000 | 0.999 | | | 1.000 | oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor |
| GO:0004146 | 1.000 | 0.997 | | | 0.999 | dihydrofolate reductase activity |
| GO:0016645 | 1.000 | 0.996 | | | 0.998 | oxidoreductase activity, acting on the CH-NH group of donors |
| GO:0048037 | 0.994 | 0.954 | | | 0.974 | cofactor binding |
| GO:0016491 | 0.980 | 0.923 | | | 0.952 | oxidoreductase activity |
| GO:0051003 | 0.854 | 0.999 | | | 0.926 | ligase activity, forming nitrogen-metal bonds, forming coordination complexes |
| GO:0004888 | 0.814 | 0.998 | | | 0.906 | transmembrane receptor activity |
| GO:0015149 | 0.774 | 0.998 | | | 0.886 | hexose transmembrane transporter activity |
| GO:0047134 | 0.712 | 1.000 | | | 0.856 | protein-disulfide reductase activity |
| GO:0003887 | 0.639 | 0.996 | | | 0.817 | DNA-directed DNA polymerase activity |
| GO:0015116 | 0.534 | 1.000 | | | 0.767 | sulfate transmembrane transporter activity |
| GO:0050485 | 0.502 | 0.999 | | | 0.750 | oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with a disulfide as acceptor |
| GO:0008171 | 0.275 | 0.999 | | | 0.637 | O-methyltransferase activity |
| GO:0009036 | 0.805 | 0.405 | | | 0.605 | Type II site-specific deoxyribonuclease activity |
| GO:0020037 | 0.196 | 0.999 | | | 0.597 | heme binding |
| GO:0016798 | 0.184 | 0.999 | | | 0.592 | hydrolase activity, acting on glycosyl bonds |
| GO:0004190 | 0.148 | 0.998 | | | 0.573 | aspartic-type endopeptidase activity |
| GO:0051002 | 0.888 | 0.248 | | | 0.568 | ligase activity, forming nitrogen-metal bonds |
| GO:0030955 | 0.124 | 0.998 | | | 0.561 | potassium ion binding |
| GO:0003711 | 0.099 | 0.996 | | | 0.548 | transcription elongation regulator activity |